ATXN1 N-terminal region explains the binding differences of wild-type and expanded forms

BMC Medical Genomics

Table 4 ATXN1 N-terminal region eukaryotic linear motifs (elm.eu.org)

Pathway	Sequence motif	Location	Proteins that bind in the region	Description	Pattern	Probability
Transcription	YSPPSAP	87–93	32	Motif recognized by class I SH3 domains	[RKY]..P..P	1.237e-03
Transcription	AWLPGNP	44–50	21		...[PV]..P	1.317e-02
Phosphorylation	SPPSAPR	88–94	31	CK1 recognition site	S..([ST])...	1.704e-02
	SPPSAPRS	88–95	32	GSK3 recognition site	...([ST])...[ST]	2.679e-02
	PVTSAVAS	154–161	21
Cell communication	PSAP	90–93	27	Glycosaminoglycan attachment site	[ED].(S)[GA]	1.792e-02
Cell communication	ASAA	160–163	24
Sumoylation	TFQFI	126–130	21	Glycosaminoglycan attachment site	[ED].(S)[GA]	1.792e-02

ATXN1 N-terminal region eukaryotic linear motifs (elm.eu.org) for which interaction is observed in more than 20 interactors showing strong interaction with expanded ATXN1

ISSN: 1755-8794