Genetic and epigenetic modifications induced by chemotherapeutic drugs: human amniotic fluid stem cells as an in-vitro model

Table 5 IC₅₀ and corresponding IC₅ values for BEP at 24,48 and 72 h

	IC₅₀ [μM]			P value^a (for IC50) corresponding to 24, 48 and 72 h	IC5 [μM] b
	24 h	48 h	72 h	P value^a (for IC50) corresponding to 24, 48 and 72 h	24 h	48 h^c	72 h
Cisplatin	50	5	3	< 0.001	5	0.5	0.3
Etoposide	300	100	40	< 0.001	30	10	4
Bleomycin	80	20	8	< 0.001	8	2	0.8

^aSignificance was determinated by ANOVA, individually for 24, 48 and 72 h
^bIC₅ used were the concentration 10X dilute than IC₅₀
^cFor uniformity, we have used IC₅ of 48 h for all the drugs throughout the study

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