Fig. 5

Protein-Protein interaction network and 5 identified sub-networks of TTR-mRNAs. The protein-protein interaction (PPI) network of 813 TTR-mRNAs was constructed with Cytoscape based on information in String database. Node size indicates surrounding gene numbers (degrees). Red node edge indicates TTR-mRNAs up-regulated in TTR groups (compared with HG group) and down-regulated in HG group (compared with LG group). Blue node edge indicates TTR-mRNAs with contrary trend. The MCODE application in Cytoscape identified 5 sub-networks. TTR-mRNAs in sub-network 1 were mainly involved in ubiquitin mediated proteolysis and cell cycle, with nodes filled in green color. TTR-mRNAs in sub-network 2 (nodes filled with purple color) were well known to influence DNA replication and cell cycle. Sub-network 3 TTR-mRNAs (nodes filled with brown color) were reported to regulate mRNA splicing via spliceosome, RNA transport, protein translation and apoptosis mediated by MAPK and NFκB pathway. Sub-network 4 TTR-mRNAs exert the role of Oxidative phosphorylation regulation and filled with blue color. TTR-mRNAs filled in orange color of Sub-network 5 participated in transcriptional regulation and DNA repair