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Table 4 MsigDB molecular signatures enrichment analysis for genes differentially expressed between MM, CM and NCM patients

From: Gene expression profiling in blood from cerebral malaria patients and mild malaria patients living in Senegal

IDa

Description

P value

FDR

GSE29617

Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from TIV influenza vaccine pre-vaccination versus those at day 3 post-vaccination.

5,16E-07

9,85E-04

GSE17721

Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 1 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 1 h.

9,56E-06

4,56E-03

GSE3337

Genes down-regulated in comparison of untreated CD8+ dendritic cells (DC) at 16 h versus those treated with IFNG [GeneID = 31,658] at 16 h.

2,75E-05

8,76E-03

GSE17721

Genes up-regulated in comparison of control dendritic cells (DC) at 4 h versus those stimulated with CpG DNA (TLR9 agonist) at 4 h.

5,22E-05

1,11E-02

GSE17721

Genes up-regulated in comparison of control dendritic cells (DC) at 2 h versus those stimulated with LPS (TLR4 agonist) at 2 h.

8,88E-05

1,54E-02

GSE19825

Genes down-regulated in comparison of naive CD8 T cells versus effector CD8 T cells.

1,34E-04

1,82E-02

GSE14308

Genes up-regulated in comparison of Th2 cells versus naive CD4 [GeneID = 620] T cells.

1,32E-04

1,94E-02

GSE17721

Genes up-regulated in comparison of dendritic cells (DC) stimulated with Gardiquimod (TLR7 agonist) at 0.5 h versus those stimulated with Gardiquimod (TLR7 agonist) at 8 h.

1,62E-04

2,07E-02

GSE9988

Genes down-regulated in comparison of monocytes treated with 5000 ng/ml LPS (TLR4 agonist) versus monocytes treated with control IgG.

2,38E-04

2,39E-02

GSE29617

Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from TIV influenza vaccinee before vaccination versus that after the vaccination.

2,70E-04

2,57E-02

GSE36476

Genes down-regulated in comparison of memory CD4 [GeneID = 920] T cells from young donors treated with TSST at 40 h versus those from old donors treated with TSST at 40 h.

4,19E-04

3,48E-02

GSE17721

Genes up-regulated in comparison of control dendritic cells (DC) at 24 h versus those stimulated with Pam3Csk4 (TLR1/2 agonist) at 24 h.

5,45E-04

4,00E-02

GSE9988

Genes down-regulated in comparison of monocytes treated with anti-TREM1 [GeneID = 54,210] and 5000 ng/ml LPS (TLR4 agonist) versus monocytes treated with control IgG.

5,41E-04

4,14E-02

GSE17721

Genes up-regulated in comparison of control dendritic cells (DC) at 12 h versus those stimulated with LPS (TLR4 agonist) at 12 h.

6,79E-04

4,32E-02

GSE25087

Genes down-regulated in comparison of fetal regulatory T cell (Treg) versus fetal conventional T cells.

2,69E-03

8,85E-02

GSE24634

Genes up-regulated in comparison of naive T cells at day 0 versus CD25+ regulatory T cell (Treg) treated with IL4 [GeneID = 3565] at day 7.

3,16E-03

9,73E-02

  1. aMsigDB molecular signatures have been selected among those that were significant