Table 6 Reactome and KEGG pathways enrichment analysis for genes differentially expressed between MM and CM patients

 Immune System

1140

70,7

136

4,47E-16

6,27E-13

 Signaling by the B Cell Receptor (BCR)

199

12,4

44

4,15E-14

1,45E-11

 Constitutive Signaling by NOTCH1 PEST Domain Mutants

59

3,67

22

1,75E-12

3,51E-10

 Downstream Signaling Events Of B Cell Receptor (BCR)

173

10,8

38

3,14E-12

5,50E-10

 Activation of NF-kappaB in B Cells

66

4,1

22

2,37E-11

3,69E-09

 Signaling by NOTCH1

74

4,6

23

4,21E-11

3,69E-09

 Signaling by ERBB4

152

9,45

33

1,26E-10

9,31E-09

 Cytokine Signaling in Immune system

286

17,8

44

1,24E-08

4,98E-07

 ER-Phagosome pathway

63

3,92

17

1,59E-07

4,04E-06

 TCR signaling

65

4,04

17

2,60E-07

5,89E-06

 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways

67

4,16

17

4,19E-07

8,51E-06

 Cross-presentation of soluble exogenous antigens

48

2,98

14

7,08E-07

1,34E-05

 TRAF6 Mediated Induction of proinflammatory cytokines

62

3,85

16

7,18E-07

1,34E-05

 Fcgamma receptor (FCGR) dependent phagocytosis

86

5,35

19

8,95E-07

1,65E-05

 Platelet activation signaling and aggregation

220

13,7

33

1,64E-06

2.84E-05

 DAP12 signaling

164

10,2

27

2,47E-06

4,23E-05

 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation

 Toll Like Receptor 7/8 (TLR7/8) Cascade

77

4,79

17

3,42E-06

5,51E-05

 TRIF-mediated TLR3/TLR4 signaling

87

5,41

18

4,73E-06

7,21E-05

 Toll Like Receptor 9 (TLR9) Cascade

79

4,91

17

4,96E-06

7,30E-05

 MyD88-independent cascade

88

5,47

18

5,61E-06

8,03E-05

 Toll Like Receptor 10 (TLR10) Cascade

74

4,6

16

8,84E-06

1,15E-04

 Toll Like Receptor 5 (TLR5) Cascade

74

4,6

16

8,84E-06

1,15E-04

Pathways from KEGG database^a

 Neurotrophin signaling pathway

123

8,75

31

1,98E-10

7,16E-09

 Bacterial invasion of epithelial cells

56

3,98

20

4,68E-10

1,45E-08

 Notch signaling pathway

47

3,34

18

9,49E-10

2,06E-08

 T cell receptor signaling pathway

98

6,97

25

9,42E-09

1,57E-07

 Endocytosis

101

7,19

23

3,59E-07

3,71E-06

 B cell receptor signaling pathway

75

5,34

19

6,75E-07

6,1E-06

 RIG-I-like receptor signaling pathway

49

3,49

12

0,000115

0,000653

 Leukocyte transendothelial migration

108

7,68

19

1,75E-04

8,61E-04

 Epithelial cell signaling in Helicobacter pylori infection

37

2,63

10

1,79E-04

8,61E-04

 Toll-like receptor signaling pathway

97

6,9

16

1,18E-03

4,64E-03

 Fc epsilon RI signaling pathway

75

5,34

12

6,10E-03

2,1E-02

 Alzheimer’s disease

49

3,49

8

2,08E-02

6,28E-02