Table 7 Reactome and KEGG pathways enrichment analysis for genes differentially expressed between MM, CM and NCM patients

 Activation of NF-kappaB in B Cells

66

7.06

31

7,21E-14

9,19E-12

 Signaling by the B Cell Receptor (BCR)

199

21.3

58

2,40E-13

2,59E-11

 Adaptive Immune System

654

69.9

128

7,82E-13

6,57E-11

 Downstream Signaling Events Of B Cell Receptor

173

18.5

51

4,45E-12

2,83E-10

 Signaling by Interleukins

116

12.4

39

1,92E-11

1,03E-09

 Signalling by NGF

290

31

67

3,70E-10

1,18E-08

 NOTCH1 Intracellular Domain Regulates Transcription

50

5.35

21

1,02E-08

2,16E-07

 ER-Phagosome pathway

63

6.74

23

4,85E-08

8,09E-07

 Platelet activation signaling and aggregation

220

23.5

50

1,23E-07

1,92E-06

 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation

76

8.13

25

1,37E-07

2,08E-06

 Toll Like Receptor 7/8 (TLR7/8) Cascade

77

8.23

25

1,82E-07

2,69E-06

 MyD88-independent cascade

88

9.41

27

2,19E-07

3,17E-06

 Toll Like Receptor 3 (TLR3) Cascade

88

9.41

27

2,19E-07

3,17E-06

 Activated TLR4 signalling

100

10.7

29

3,02E-07

4,22E-06

 Fcgamma receptor (FCGR) dependent phagocytosis

86

9.2

26

5,07E-07

6,71E-06

 Toll Like Receptor 4 (TLR4) Cascade

103

11

29

6,01E-07

7,80E-06

Pathways from KEGG database^a

Total

Expected

Hits

P value

FDR

 T cell receptor signaling pathway

98

11,1

35

1,15E-10

5E-09

 Bacterial invasion of epithelial cells

56

6,32

24

1,47E-09

4,55E-08

 B cell receptor signaling pathway

75

8,46

25

2,66E-07

2,8E-06

 Fc gamma R-mediated phagocytosis

97

10,9

28

1,46E-06

1,22E-05

 Endocytosis

101

11,4

27

1,11E-05

6,88E-05

 TGF-beta signaling pathway

84

9,48

20

8,03E-04

3,71E-03

 Fc epsilon RI signaling pathway

75

8,46

18

1,31E-03

5,48E-03

 Toll-like receptor signaling pathway

97

10,9

21

2,19E-03

8,64E-03

 RIG-I-like receptor signaling pathway

49

5,53

12

6,85E-03

2,25E-02

 Alzheimer’s disease

49

5,53

11

1,82E-02

5,41E-02

 Natural killer cell mediated cytotoxicity

138

15,6

23

3,41E-02

9,37E-02