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Fig. 2 | BMC Medical Genomics

Fig. 2

From: Whole-genome bisulfite sequencing in systemic sclerosis provides novel targets to understand disease pathogenesis

Fig. 2

Biological impacts of differential methylation. (a) Significantly enriched canonical pathways (p < 0.05) based on CpG-DMRs. Pathways are sorted by p values. Percentage (indicated by bars) represents the proportion of significantly hypermethylated (red) and hypomethylated (green) genes among all genes in the corresponding pathway. Log-transformed p values are denoted by the orange line. (b) Top 10 differentially methylated genes with largest averaged difference in methylation levels in CpG-DMRs related to skin lesions. Five most hypermethylated genes (red) and five most hypomethylated genes (green) in SSc are illustrated

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BMC Medical Genomics

ISSN: 1755-8794

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