Table 4 Top five diseases influenced by CHH differential methylation

Familial skeletal dysplasia

ADAMTS2, DDR2, FAM20C, FDFT1, MYO18B, PDE4D, ROR2, TNFRSF11A

3.06E-07

Large intestine adenocarcinoma

ADAMTS2, AGT, ATXN3L, BAIAP2L1, CCDC155, CCDC85C, CFAP299, CMIP, CNNM2, CTDP1, DDR2, DNAJB13, FAM20C, FDFT1, FPR3, GAS7, GCM1, GRID2, IL13, IL27, IQCE, ITPK1, KCNJ12, KRT38, MCEE, MYO18B, NAV2, NDUFA10, NPHP4, PCSK6, PDE4D, PGS1, PITPNC1, PLEKHF1, PLEKHM3, PRKCA, PTPRN2, RALGPS2, RASA3, RIMBP2, RIN2, ROR2, RPS19, SLC30A1, SLC6A12, SPATS2L, SPG7, SV2C, TDRD5, TMEM92, TNFRSF11A, ZFYVE28

2.34E-06

Hereditary connective tissue disorder

ADAMTS2, AGT, CTDP1, DDR2, FAM20C, FDFT1, JDP2, MYO18B, PDE4D, RIN2, ROR2, TNFRSF11A

2.76E-06

Abdominal adenocarcinoma

ADAMTS2, AGT, ATXN3L, BAIAP2L1, CCDC155, CCDC85C, CFAP299, CMIP, CNNM2, CPNE6, CTDP1, DDR2, DNAJB13, FAM20C, FDFT1, FPR3, GAS7, GCM1, GRID2, IL13, IL27, IQCE, ITPK1, KCNJ12, KRT38, MCEE, MYO18B, NAV2, NDUFA10, NPHP4, PCSK6, PDE4D, PGS1, PITPNC1, PLEKHF1, PLEKHM3, PRKCA, PTPRN2, RALGPS2, RASA3, RIMBP2, RIN2, ROR2, RPS19, SLC30A1, SLC6A12, SPATS2L, SPG7, SSR1, SV2C, TDRD5, TMEM92, TNFRSF11A, ZFYVE28

8.89E-05

Liver carcinoma

ADAMTS2, AGT, CNNM2, CTDP1, DDR2, DNAJB13, FAM20C, FPR3, GAS7, GRID2, IL27, IQCE, JDP2, KCNJ12, MYO18B, NAV2, NDUFA10, NPHP4, PDE4D, PGS1, PITPNC1, PTPRN2, RALGPS2, RASA3, RIMBP2, RIN2, SLC30A1, SLC6A12, TDRD5, TNFRSF11A, ZFYVE28

2.32E-04