From: Classification of glioma based on prognostic alternative splicing
 | ST1(n = 49) | ST2(n = 49) | ST3(n = 56) | Total(n = 154) |
---|---|---|---|---|
Clinical | ||||
 Age | ||||
  Median | 62.8 | 60.1 | 61.0 | 60.24 |
  No. ≤ 40 years old | 1 | 5 | 6 | 12 |
Survival (in months) | ||||
 Median (CI) | 9.0 (5.47, 12.8) | 15.1 (13.5, 17.7) | 15.6 (13.5–25.5) | 13.8 (12.1–15.3) |
Disease-free survival (in months) | ||||
 Median (CI) | 8.4 (6.0, NA) | 8.5 (6.7 13.1) | 11 (5.9, NA) | 8.5 (6.7, 13) |
Karnofsky score | ||||
 100 | 2 | 2 | 7 | 11 |
 90 | 0 | 2 | 0 | 2 |
 70–80 | 19 | 25 | 19 | 63 |
  < 70 | 8 | 6 | 16 | 30 |
Sex | ||||
 Female | 18 | 20 | 16 | 54 |
 Male | 31 | 29 | 40 | 100 |
Molecular | ||||
 IDH Status | ||||
  Mutant | 0 | 3 | 7 | 10 |
  WT | 46 | 45 | 49 | 140 |
 MGMT Promoter | ||||
  Methylated | 11 | 17 | 24 | 52 |
  Unmethylated | 26 | 24 | 21 | 71 |
 G-CIMP Methylation | ||||
  G-CIMP | 0 | 2 | 6 | 8 |
  Non-G-CIMP | 48 | 46 | 50 | 144 |
 TERT Promoter | ||||
  Mutant | 4 | 9 | 12 | 25 |
  WT | 45 | 39 | 41 | 4 |
 TERT Expression | ||||
  Expressed | 38 | 42 | 47 | 127 |
  Not.expressed | 10 | 7 | 9 | 26 |
 CHR7 Gain CHR10 loss | ||||
  Gain chr7&loss chr10 | 31 | 32 | 34 | 97 |
  No combined CNA | 18 | 13 | 20 | 51 |
 CHR19/20 co gain | ||||
  Gain chr19/20 | 2 | 5 | 12 | 19 |
  No chr19/20 gain | 47 | 40 | 42 | 129 |
Clusters | ||||
 Transcriptome Cluster | ||||
  CL | 49 | 26 | 7 | 1 |
  MC | 66 | 16 | 8 | 6 |
  NE | 5 | 1 | 19 | 9 |
  PN | 18 | 3 | 72 | 61 |
 Original Cluster | ||||
  Classical | 39 | 0 | 0 | 0 |
  G-CIMP | 7 | 0 | 1 | 0 |
 IDHmut-codel | 0 | 1 | 23 | 20 |
  IDHmut-non-codel | 0 | 4 | 127 | 67 |
  IDHwt | 0 | 49 | 21 | 6 |
  Mesenchymal | 50 | 0 | 0 | 0 |
  Neural | 26 | 0 | 0 | 0 |
  Proneural | 29 | 0 | 0 | 0 |
 Pan-Glioma RNA Expression Cluster | ||||
  LGr1 | 20 | 4 | 25 | 17 |
  LGr2 | 3 | 0 | 0 | 2 |
  LGr3 | 9 | 4 | 127 | 68 |
  LGr4 | 121 | 46 | 20 | 6 |
 Pan-Glioma DNA Methylation Cluster | ||||
  LGm1 | 7 | 4 | 18 | 11 |
  LGm2 | 1 | 0 | 120 | 59 |
  LGm3 | 0 | 1 | 14 | 19 |
  LGm4 | 43 | 14 | 4 | 0 |
  LGm5 | 59 | 30 | 12 | 0 |
  LGm6 | 12 | 5 | 5 | 5 |