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Table 1 The top 10 genes with higher weights

From: A new method for mining information of co-expression network based on multi-cancers integrated data

Gene

Summary

 ASXL2

This gene encodes a member of a family of epigenetic regulators that bind various histone-modifying enzymes and are involved in the assembly of transcription factors at specific genomic loci.

 BUB1B

This gene encodes a kinase involved in spindle checkpoint function.

 MYO1F

The protein encoded by this gene is an unconventional myosin that may be involved in the intracellular movement of membrane-enclosed compartments.

 CLEC14A

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation.

 KIF11

This gene encodes a motor protein that belongs to the kinesin-like protein family.

 SASH3

The protein encoded by this gene contains a Src homology-3 (SH3) domain and a sterile alpha motif (SAM), both of which are found in proteins involved in cell signaling.

 KLHL41

The encoded protein by this gene contains a BACK domain, a BTB/POZ domain, and 5 Kelch repeats. This protein is thought to function in skeletal muscle development and maintenance.

 MYOZ1

The protein encoded by this gene is primarily expressed in the skeletal muscle, and belongs to the myozenin family.

 TPX2

This gene is a Protein Coding gene. Diseases associated with TPX2 include Hepatocellular Carcinoma

 CD48

This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins.

  1. The bold data are cancer-related genes