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Table 3 Current practice in communication of reclassified variants from laboratory to clinician

From: Reinterpretation, reclassification, and its downstream effects: challenges for clinical laboratory geneticists

 Reclassificatsion
B (1)LB (2)VUS (3)LP (4)P (5)
Initial classificationB (1) NOVariesYESYES
LB (2)NO VariesYESYES
VUS (3)VariesVaries YESYES
LP (4)YESYESYES YES
P (5)YESYESYESVaries 
  1. Variants are shown with their initial classification and after reclassification, ranging from class 1 to class 5 (representing benign, likely benign, variant of uncertain significance, likely pathogenic, and pathogenic)
  2. Yes - This type of reclassification is communicated from laboratory to clinician
  3. No - This type of reclassification is not communicated from laboratory to clinician
  4. Varies - Communication of this type of reclassification from laboratory to clinician varies between laboratory geneticists
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