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Fig. 2 | BMC Medical Genomics

Fig. 2

From: High-throughput RNA sequencing from paired lesional- and non-lesional skin reveals major alterations in the psoriasis circRNAome

Fig. 2

The circRNAome is massively downregulated in lesional- relative to non-lesional skin. (a) Venn diagram illustrating the overlap of circRNAs detected in the lesional- and the non-lesional skin. (b) Scatter plot showing that the average expression in reads per million (RPM) of the 298 unique high-abundance circRNAs is lower in lesional- relative to non-lesional skin. (c) Volcano plot of the 298 unique high-abundance circRNAs showing fold changes in circRNA expression in RPM between lesional- and non-lesional skin according to the levels of significance. The top 50 most abundant circRNAs are indicated in green. (d) Scatter plot of fold changes in RPM and fold changes in circular-to-linear (CTL) ratios of the high abundance circRNAs. It can be observed that most circRNAs were downregulated independently of their respective host genes (defined as those being present in between the blue lines)

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BMC Medical Genomics

ISSN: 1755-8794

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