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Fig. 3 | BMC Medical Genomics

Fig. 3

From: High-throughput RNA sequencing from paired lesional- and non-lesional skin reveals major alterations in the psoriasis circRNAome

Fig. 3

Analyses of factors known to regulate circRNA biogenesis in lesional- relative to non-lesional skin. (a) RNA-seq analyses revealed that ADAR was the most differentially expressed of the analyzed factors. (b) NanoString nCounter analysis confirmed that ADAR is upregulated in lesional- relative to non-lesional skin. (c) Volcano plot of the 298 unique high-abundance circRNAs showing fold changes in circRNA expression in RPM between lesional- and non-lesional skin according to the levels of significance. One-hundred thirty-one circRNAs likely to have Alu-mediated biogenesis are indicated in green (flanked by IAEs within 2300 nucleotide regions flanking the BSJs). The numbers of circRNAs in each category are shown in the inserted table. There was no statistically significant association between downregulation of circRNAs (more than 2 fold) and the presence of flanking IAEs (P = 0.75, chi-squared test)

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