Skip to main content
Fig. 4 | BMC Medical Genomics

Fig. 4

From: High-throughput RNA sequencing from paired lesional- and non-lesional skin reveals major alterations in the psoriasis circRNAome

Fig. 4

The downregulation of circRNAs, mainly observed in the epidermis, is unlikely to be caused by infiltrating lymphocytes. (a) Representative H&E staining of lesional- and non-lesional skin samples showing a relative abundance of lymphocytes in the dermis of the lesional skin. (b) RNA-seq data showed that T-cell specific genes were expressed at higher levels in the lesional skin- relative to non-lesional skin. (c-d) Following microdissection of the epidermis and NanoString nCounter analysis, five of seven circRNAs were shown to be significantly downregulated in the epidermis of the lesional skin (c), while this only applied to one of seven circRNAs analyzed in the dermis (d). (e-f) ADAR proved to be significantly upregulated both in the epidermis (e) and the dermis (f) of the lesional skin

Back to article page

BMC Medical Genomics

ISSN: 1755-8794

Contact us