Table 2 Cociter analysis of top 30 prostate cancer driver genes identified by our method
Genes | Cancer | Prostate | Driver | is driver | DyTidriver | Diffusion | DriverNet | DawnRank | Muf max | Muf sum |
|---|---|---|---|---|---|---|---|---|---|---|
TP53 | 6772 | 298 | 110 | 1 | 1 | 1 | 1 | 1 | 38 | 4 |
CTNNB1 | 2517 | 170 | 44 | 1 | 2 | 2 | 2 | 21 | 40 | 9 |
ASH1L | 4 | 0 | 1 | 0 | 3 | 1703 | NA | NA | 653 | 78 |
SPOP | 43 | 24 | 4 | 1 | 4 | 1721 | 3 | 169 | 8 | 3 |
ATM | 1377 | 61 | 5 | 0 | 5 | 13 | 11 | 12 | 36 | 14 |
PTEN | 3047 | 642 | 64 | 1 | 6 | 700 | 94 | NA | 39 | 37 |
TTN | 10 | 0 | 2 | 0 | 7 | 1724 | 22 | 14 | 2 | 2 |
FOXA1 | 182 | 69 | 10 | 0 | 8 | 17 | 5 | 3 | 37 | 10 |
KMT2D | 25 | 2 | 2 | 0 | 9 | 855 | 54 | NA | NA | NA |
PIK3CA | 1199 | 34 | 54 | 1 | 10 | 7 | 10 | NA | 282 | 36 |
DYNC1H1 | 9 | 1 | 2 | 0 | 11 | 66 | 19 | 51 | 219 | 72 |
CDH12 | 4 | 0 | 0 | 0 | 12 | 1511 | NA | 755 | 349 | 296 |
BRAF | 2175 | 33 | 126 | 1 | 13 | 326 | 63 | 36 | 348 | 34 |
AKT1 | 2152 | 317 | 23 | 1 | 14 | 20 | 23 | NA | 52 | 33 |
FAT3 | 1 | 1 | 1 | 0 | 15 | 19 | 26 | 75 | NA | NA |
LRP4 | 7 | 0 | 2 | 0 | 16 | 1440 | NA | NA | 1426 | 541 |
GRIN2B | 13 | 0 | 2 | 0 | 17 | 74 | 33 | NA | 220 | 90 |
KMT2C | 23 | 2 | 4 | 0 | 18 | 613 | 27 | NA | NA | NA |
NCOR1 | 109 | 27 | 3 | 1 | 19 | 59 | 77 | 58 | 41 | 60 |
HSPA8 | 96 | 9 | 1 | 0 | 20 | 10 | 8 | NA | 438 | 67 |
OBSCN | 7 | 0 | 0 | 0 | 21 | 1714 | 168 | 408 | 1 | 24 |
GRIN2A | 5 | 0 | 1 | 0 | 22 | 285 | 92 | 85 | 374 | 73 |
PCDHA12 | 1 | 0 | 0 | 0 | 23 | 1453 | 271 | 197 | 324 | 65 |
MED12 | 19 | 4 | 4 | 0 | 24 | 376 | 162 | 157 | 317 | 84 |
STAT3 | 1824 | 147 | 27 | 0 | 25 | 16 | 15 | 5 | 58 | 8 |
PCDH18 | 2 | 1 | 1 | 0 | 26 | 1656 | 93 | 66 | 262 | 39 |
CDH23 | 5 | 0 | 1 | 0 | 27 | 457 | 97 | NA | 295 | 63 |
SPTA1 | 3 | 0 | 1 | 0 | 28 | 1719 | 16 | 9 | 221 | 15 |
UFL1 | 7 | 0 | 1 | 0 | 29 | NA | NA | NA | 1238 | 1265 |
SP1 | 393 | 38 | 3 | 1 | 30 | 8 | 9 | NA | 86 | 5 |