HPOAnnotator: improving large-scale prediction of HPO annotations by low-rank approximation with HPO semantic similarities and multiple PPI networks

Table 7 Training times of a single run in 5 ×5-fold cross-validation (average over 25 runs)

Method	Computation time
LR	∼3.5 hours
BiRW	∼1.5 hours
OGL, DLP	≥4 hours
NMF, NMF-PPN, NMF-NHPO, HPOAnnotator	∼30 minutes

ISSN: 1755-8794