Fig. 11

Clonal trees identified for patient CLL077. The left panel shows the tree derived from deep sequencing and the right panel shows the tree from WGS data. These trees were the max-weight spanning trees of the respective approximate ancestry graphs. Edge weights are the probability of the relationship and color labels correspond to clusters in Fig. 10. The movement of OCA2 to the root is due to different clustering as a result of noise (see Fig. 10). DDX1, ZFHX4, and ZNF566 were not represented in the deep sequencing data, while GPR158 was filtered out in the deep sequencing data due to VAF over 0.5. The WGS tree required a sum condition relaxation of ε=0.048