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Table 4 Most significant GO and KEGG pathways enriched in PBMC clusters

From: Analysis of gene expression profiles and protein-protein interaction networks in multiple tissues of systemic sclerosis

Go Biological Process

P-value

KEGG Pathway

P-value

Cluster P.1 (Inflammation and immunity) - size/DEGs = 7/7

 - type I interferon signaling pathway

1.16E-07

None

 - cellular response to type I interferon

1.16E-07

 - endosomal vesicle fusion

0.000119

 - cytokine-mediated signaling pathway

0.000503

 - negative regulation of viral genome replication

0.001647

Cluster P.2 (Inflammation and immunity) - size/DEGs = 9/9

 - response to organophosphorus

5.96E-06

- Apoptosis

1.16E-07

 - response to purine-containing compound

5.96E-06

- Osteoclast differentiation

6.68E-06

 - response to cytokine

1.34E-05

- TNF signaling pathway

0.000265

 - cellular response to organic substance

1.34E-05

- Influenza A

0.000798

 - response to cAMP

2.61E-05

- Viral carcinogenesis

0.001022