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Table 5 Most significant GO and KEGG pathways enriched in skin clusters

From: Analysis of gene expression profiles and protein-protein interaction networks in multiple tissues of systemic sclerosis

Go Biological ProcessP-valueKEGG PathwayP-value
cluster S.1 (ECM organization) - size/DEGs = 11/11
 - extracellular matrix organization9.32E-10- Protein digestion and absorption7.46E-09
 - skeletal system development5.4E-07- ECM-receptor interaction5.35E-05
 - eye morphogenesis6.6E-06- Focal adhesion0.000526
 - collagen fibril organization1.51E-05- PI3K-Akt signaling pathway0.001831
 - eye development3.74E-05 
cluster S.2 (Inflammation and immunity) - size/DEGs = 14/14
 - inflammatory response3.4E-06- Legionellosis3.16E-06
 - neutrophil mediated immunity5.53E-05- Pertussis5.59E-06
 - cellular response to cytokine stimulus5.53E-05- Rheumatoid arthritis7.79E-06
 - response to lipopolysaccharide0.000268- TNF signaling pathway1.31E-05
 - positive regulation of apoptotic cell clearance0.000619- Phagosome4.02E-05
cluster S.3 (ECM organization) - size/DEGs = 7/7
 - platelet degranulation1.5E-08- Complement and coagulation cascades0.002555
 - regulated exocytosis1.83E-08 
 - extracellular matrix organization1.08E-07
 - post-translational protein modification0.003869
 - extracellular matrix disassembly0.005238
cluster S.4 (Inflammation and immunity) - size/DEGs = 5/5
 - type I interferon signaling pathway0.001321- RIG-I-like receptor signaling pathway0.01738
 - negative regulation of viral genome replication0.001321 
 - negative regulation of viral life cycle0.001321
 - cellular response to type I interferon0.001321
 - regulation of viral genome replication0.001321