Table 5 Most significant GO and KEGG pathways enriched in skin clusters
Go Biological Process | P-value | KEGG Pathway | P-value |
|---|---|---|---|
cluster S.1 (ECM organization) - size/DEGs = 11/11 | |||
 - extracellular matrix organization | 9.32E-10 | - Protein digestion and absorption | 7.46E-09 |
 - skeletal system development | 5.4E-07 | - ECM-receptor interaction | 5.35E-05 |
 - eye morphogenesis | 6.6E-06 | - Focal adhesion | 0.000526 |
 - collagen fibril organization | 1.51E-05 | - PI3K-Akt signaling pathway | 0.001831 |
 - eye development | 3.74E-05 |  | |
cluster S.2 (Inflammation and immunity) - size/DEGs = 14/14 | |||
 - inflammatory response | 3.4E-06 | - Legionellosis | 3.16E-06 |
 - neutrophil mediated immunity | 5.53E-05 | - Pertussis | 5.59E-06 |
 - cellular response to cytokine stimulus | 5.53E-05 | - Rheumatoid arthritis | 7.79E-06 |
 - response to lipopolysaccharide | 0.000268 | - TNF signaling pathway | 1.31E-05 |
 - positive regulation of apoptotic cell clearance | 0.000619 | - Phagosome | 4.02E-05 |
cluster S.3 (ECM organization) - size/DEGs = 7/7 | |||
 - platelet degranulation | 1.5E-08 | - Complement and coagulation cascades | 0.002555 |
 - regulated exocytosis | 1.83E-08 |  | |
 - extracellular matrix organization | 1.08E-07 | ||
 - post-translational protein modification | 0.003869 | ||
 - extracellular matrix disassembly | 0.005238 | ||
cluster S.4 (Inflammation and immunity) - size/DEGs = 5/5 | |||
 - type I interferon signaling pathway | 0.001321 | - RIG-I-like receptor signaling pathway | 0.01738 |
 - negative regulation of viral genome replication | 0.001321 |  | |
 - negative regulation of viral life cycle | 0.001321 | ||
 - cellular response to type I interferon | 0.001321 | ||
 - regulation of viral genome replication | 0.001321 | ||