Table 4 Functional enrichment analysis of the genes in the prognostic gene pairs for breast cancer
From: Finding prognostic gene pairs for cancer from patient-specific gene networks
| Â | Â | #genes | p-value | FDR |
|---|---|---|---|---|
Annotation cluster 1 | Enrichment score: 13.55 | Â | Â | Â |
KEGG_PATHWAY | hsa05200:Pathways in cancer | 36 | 1.64E-22 | 1.98E-19 |
KEGG_PATHWAY | hsa05215:Prostate cancer | 15 | 1.40E-12 | 1.70E-09 |
KEGG_PATHWAY | hsa04151:PI3K-Akt signaling pathway | 19 | 9.74E-08 | 1.18E-04 |
Annotation cluster 2 | Enrichment score: 7.93 | Â | Â | Â |
KEGG_PATHWAY | hsa04510:Focal adhesion | 18 | 2.31E-10 | 2.80E-07 |
KEGG_PATHWAY | hsa05205:Proteoglycans in cancer | 16 | 1.13E-08 | 1.37E-05 |
KEGG_PATHWAY | hsa04015:Rap1 signaling pathway | 16 | 2.20E-08 | 2.66E-05 |
KEGG_PATHWAY | hsa05100:Bacterial invasion of epithelial cells | 10 | 3.23E-07 | 3.91E-04 |
Annotation cluster 3 | Enrichment score: 6.62 | Â | Â | Â |
UP_KEYWORDS | Growth factor | 11 | 7.37E-09 | 9.42E-06 |
GOTERM_MF_DIRECT | GO:0008083 growth factor activity | 12 | 2.54E-08 | 3.52E-05 |
GOTERM_BP_DIRECT | GO:0050679 positive regulation of epithelial cell proliferation | 6 | 7.40E-05 | 1.25E-01 |
Annotation cluster 4 | Enrichment score: 5.44 | Â | Â | Â |
GOTERM_MF_DIRECT | GO:0044212 transcription regulatory region DNA binding | 13 | 4.59E-08 | 6.36E-05 |
GOTERM_BP_DIRECT | GO:0045893 positive regulation of transcription, DNA-templated | 17 | 9.99E-07 | 1.69E-03 |
GOTERM_BP_DIRECT | GO:0045892 negative regulation of transcription, DNA-templated | 12 | 1.03E-03 | 1.73E-00 |