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Table 3 The number of pathogenic mutations identified in 208 paired tumour-blood samples in five genes that are frequently mutated in ovarian cancer. The number of unique mutations is shown and in brackets the number of samples with at least one mutation is shown

From: Comparison of somatic variant detection algorithms using Ion Torrent targeted deep sequencing data

 

BRCA1

BRCA2

KRAS

PIK3CA

TP53

MuTect2

1056 (n = 207)

364 (n = 207)

51 (n = 157)

45 (n = 137)

738 (n = 208)

TVC

126 (n = 83)

30 (n = 38)

10 (n = 31)

16 (n = 27)

139 (n = 139)

VarScan2

94 (n = 188)

57 (n = 194)

7 (n = 19)

10 (20)

111 (n = 161)

Common

33 (n = 77)

8 (n = 34)

7 (n = 17)

7 (n = 15)

81 (n = 122)

Common (%)

2.9% (37%)

2.1% (16.4%)

13.7% (10.8%)

14.9% (10.6%)

10.7% (57.8%)