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Table 2 5 year Overall Survival in TCGA breast cancer cohort based upon regulon activity or gene expression

From: RNA-seq from archival FFPE breast cancer samples: molecular pathway fidelity and novel discovery

TCGA Breast Cancer: n = 897

Single Sample Regulon Activity

Single Sample Gene Expression Value

Regulon

Gene

HR (Hi/Lo)

p value (Log-Rank)

End survival % (Hi/Lo)

HR (Hi/Lo)

p value (Log-Rank)

End Survival % (Hi/Lo)

CCNH

0.3864

0.0001

90/78

0.6962

0.1258

86/82

TBC1D9

0.4976

0.0043

89/80

0.4555

0.0014

89/79

CXXC5

0.4641

0.002

90/79

0.7015

0.1409

86/82

KDM4B

0.3221

<.0001

92/77

0.3786

<.0001

90/78

VGLL1

1.108

0.663

85/84

1.46

0.1114

82/86

FOXM1

2.065

0.0029

80/89

1.993

0.0044

80/89

SUV39H2

2.929

<.0001

77/92

2.279

0.0009

79/90

YEATS2

3.434

<.0001

76/92

1.429

0.1292

82/87

  1. RNA expression data from 897 female primary breast cancer patients under the age of 76 was obtained from the TCGA cohort and stratified to either the high (Hi) or low (Lo) group for each of the individual indicated regulons or genes based upon median values for regulon activity or gene expression (depicted in Additional file 4: Figure S4b). Five year overall survival distribution was determined and Hazard Ratio (HR) expressed as risk comparing the high (Hi) expression/activity to the low (Lo) group. Log-rank p-values are displayed and the final frequency of survival at 5 years post diagnosis indicated for the high and low groups (Hi/Lo)