Table 1 Gene ontology analysis of differentially expressed genes associated with RMS
Expression | Category | Term/gene function | Gene count | % | P Value |
|---|---|---|---|---|---|
Up-regulated | GOTERM_BP_DIRECT | GO:0006351~transcription, DNA-templated | 193 | 13.23731 | 1.13E-05 |
GOTERM_BP_DIRECT | GO:0006355~regulation of transcription, DNA-templated | 160 | 10.97394 | 1.19E-06 | |
GOTERM_BP_DIRECT | GO:0051301~cell division | 104 | 7.133059 | 4.72E-36 | |
GOTERM_BP_DIRECT | GO:0007067~mitotic nuclear division | 65 | 4.458162 | 1.67E-19 | |
GOTERM_BP_DIRECT | GO:0000086~G2/M transition of mitotic cell cycle | 40 | 2.743484 | 7.88E-14 | |
GOTERM_CC_DIRECT | GO:0005634~nucleus | 533 | 36.55693 | 1.64E-19 | |
GOTERM_CC_DIRECT | GO:0005737~cytoplasm | 462 | 31.68724 | 2.38E-08 | |
GOTERM_CC_DIRECT | GO:0005654~nucleoplasm | 316 | 21.67353 | 7.16E-19 | |
GOTERM_CC_DIRECT | GO:0005829~cytosol | 287 | 19.6845 | 1.93E-04 | |
GOTERM_CC_DIRECT | GO:0016020~membrane | 208 | 14.26612 | 1.29E-05 | |
GOTERM_MF_DIRECT | GO:0005515~protein binding | 763 | 52.33196 | 8.43E-14 | |
GOTERM_MF_DIRECT | GO:0046872~metal ion binding | 201 | 13.78601 | 8.80E-06 | |
GOTERM_MF_DIRECT | GO:0003677~DNA binding | 187 | 12.82579 | 1.09E-09 | |
GOTERM_MF_DIRECT | GO:0003676~nucleic acid binding | 122 | 8.367627 | 5.09E-09 | |
GOTERM_MF_DIRECT | GO:0044822~poly(A) RNA binding | 108 | 7.407407 | 0.002521 | |
Down-regulated | GOTERM_BP_DIRECT | GO:0006936~muscle contraction | 33 | 7.875895 | 4.20E-28 |
GOTERM_BP_DIRECT | GO:0030049~muscle filament sliding | 25 | 5.966587 | 3.00E-31 | |
GOTERM_BP_DIRECT | GO:0060048~cardiac muscle contraction | 18 | 4.295943 | 1.81E-17 | |
GOTERM_BP_DIRECT | GO:0045214~sarcomere organization | 14 | 3.341289 | 8.14E-15 | |
GOTERM_BP_DIRECT | GO:0007517~muscle organ development | 14 | 3.341289 | 5.27E-08 | |
GOTERM_CC_DIRECT | GO:0005829~cytosol | 105 | 25.05967 | 1.97E-06 | |
GOTERM_CC_DIRECT | GO:0030018~Z disc | 42 | 10.02387 | 1.26E-39 | |
GOTERM_CC_DIRECT | GO:0015629~actin cytoskeleton | 21 | 5.011933 | 2.35E-08 | |
GOTERM_CC_DIRECT | GO:0030017~sarcomere | 17 | 4.057279 | 1.58E-17 | |
GOTERM_CC_DIRECT | GO:0031430~M band | 16 | 3.818616 | 1.41E-20 | |
GOTERM_MF_DIRECT | GO:0003779~actin binding | 39 | 9.307876 | 3.74E-20 | |
GOTERM_MF_DIRECT | GO:0042803~protein homodimerization activity | 29 | 6.921241 | 0.001951 | |
GOTERM_MF_DIRECT | GO:0008307~structural constituent of muscle | 24 | 5.727924 | 5.18E-28 | |
GOTERM_MF_DIRECT | GO:0005516~calmodulin binding | 18 | 4.295943 | 6.18E-07 | |
GOTERM_MF_DIRECT | GO:0051015~actin filament binding | 16 | 3.818616 | 1.39E-07 |