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Fig. 3 | BMC Medical Genomics

Fig. 3

From: Genome-wide analysis of aberrant methylation of enhancer DNA in human osteoarthritis

Fig. 3

Gender-specific enhancer methylation related to osteoarthritis phenotypes in hip osteoarthritis. a The number of gender-specific eDMCs identified in the hip OA group and hip NC group. b Two-way hierarchical clustering of methylation in the gender-specific eDMCs across hip samples. Each row represents a gender-specific eDMC, and each column represents a sample colored by two colors: purple for females and blue for males. DNA methylation (β value) is represented by a color from dark blue (unmethylated) to dark red (fully methylated). c The fraction of the eDMCs in cluster 1 and cluster 2. d Human phenotypes enriched by genes near the eDMCs in cluster 2. The length of each bar represents the significance of the phenotype enriched by eDMCs in cluster 2. Detailed information can be found in Additional file 4: Table S2. e The eDMC-gene pair for the eDMCs enriched in the osteoarthritis phenotype. f The genome context of the eDMCs related to the gene COL11A2, which was made by the UCSC genome browser

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