Fig. 5

Organ source-dependent differences in enhancer methylation between patients with hip OA and knee OA. a The eDMCs between hip OA and knee OA did not overlap with those between hip OA and hip CT. b Two-way hierarchical clustering of methylation in the eDMCs between hip OA and knee OA. Each row represents an eDMC, and each column represents a sample. The methylation levels of these eDMCs in the hip CT group are shown according to the row order determined by hierarchical clustering. DNA methylation (β value) is represented by a color from dark blue (unmethylated) to dark red (fully methylated). c The top 10 human phenotypes enriched in the genes near the eDMCs in cluster 1 in Figure b. d The top 10 human phenotypes enriched in the genes near the eDMCs in cluster 2 in Figure b