MiR-182-5p and its target HOXA9 in non-small cell lung cancer: a clinical and in-silico exploration with the combination of RT-qPCR, miRNA-seq and miRNA-chip

Table 1 MiR-182-5p expression in LUAD data from RT-qPCR

Clinicopathological parameters		n	Relevant expression of miR-182-5p (2^−ΔCq)
Clinicopathological parameters		n	Mean ± SD	t/F-value	p-value
Tissue	LUAD	101	30.371 ± 5.475	14.035	< 0.001*
Tissue	Noncancerous	101	22.908 ± 3.728	14.035	< 0.001*
Gender	Male	56	29.923 ± 5.567	1.150	0.253
Gender	Female	45	28.609 ± 5.879	1.150	0.253
Age (years)	< 60	41	30.642 ± 5.238	1.964	0.053
Age (years)	≥60	60	28.446 ± 5.899	1.964	0.053
Smoke	No	26	31.159 ± 5.435	0.602	0.550
Smoke	Yes	18	30.138 ± 5.671	0.602	0.550
Tumor size	≤3 cm	53	25.041 ± 4.651	−13.541	< 0.001*
Tumor size	> 3 cm	48	34.082 ± 1.343	−13.541	< 0.001*
Vascular invasion	No	70	28.986 ± 5.839	−0.927	0.356
Vascular invasion	Yes	31	30.130 ± 5.441	−0.927	0.356
TNM	I-II	44	26.730 ± 5.442	−4.377	< 0.001*
TNM	III-IV	57	31.350 ± 5.114	−4.377	< 0.001*
Lymph node metastasis	No	45	26.478 ± 5.243	−5.023	< 0.001*
Lymph node metastasis	Yes	56	31.635 ± 5.036	−5.023	< 0.001*
Pathological grading	I	17	27.642 ± 5.863	0.915^b	0.404
	II	61	29.753 ± 5.713
	III	23	29.489 ± 5.641

ISSN: 1755-8794