MiR-182-5p and its target HOXA9 in non-small cell lung cancer: a clinical and in-silico exploration with the combination of RT-qPCR, miRNA-seq and miRNA-chip

Table 2 MiR-182-5p expression in NSCLC data from RT-qPCR

Clinicopathological parameters		n	Relevant expression of miR-182-5p (2^−ΔCq)
Clinicopathological parameters		n	Mean ± SD	t/F-value	p-value
Tissue	NSCLC	124	29.615 ± 5.616	13.979	< 0.001*
Tissue	Noncancerous	124	22.859 ± 3.669	13.979	< 0.001*
Gender	Male	74	30.144 ± 5.497	1.278	0.204
Gender	Female	50	28.833 ± 5.755	1.278	0.204
Age (years)	< 60	56	30.913 ± 5.052	2.413	0.017*
Age (years)	≥60	68	28.547 ± 5.864	2.413	0.017*
Smoke	No	38	31.184 ± 5.185	0.720	0.474
Smoke	Yes	29	30.237 ± 5.530	0.720	0.474
Histological type	Adenocarcinoma	101	29.337 ± 5.717	−1.245	0.221
Histological type	Squamous carcinoma	23	30.836 ± 5.086	−1.245	0.221
Tumor size	≤3 cm	60	24.995 ± 4.570	−14.353	< 0.001*
Tumor size	> 3 cm	64	33.947 ± 1.620	−14.353	< 0.001*
Vascular invasion	No	90	29.456 ± 5.720	−0.512	0.609
Vascular invasion	Yes	34	30.037 ± 5.391	−0.512	0.609
TNM	I-II	54	27.131 ± 5.424	−4.632	< 0.001*
TNM	III-IV	70	31.532 ± 5.007	−4.632	< 0.001*
Lymph node metastasis	No	56	26.621 ± 5.128	−6.095	< 0.001*
Lymph node metastasis	Yes	68	32.081 ± 4.759	−6.095	< 0.001*
Pathological grading	I	17	27.642 ± 5.863	1.246^a	0.291
	II	77	29.853 ± 5.721
	III	30	30.124 ± 5.131

ISSN: 1755-8794