MiR-182-5p and its target HOXA9 in non-small cell lung cancer: a clinical and in-silico exploration with the combination of RT-qPCR, miRNA-seq and miRNA-chip

Table 4 MiR-182-5p expression in NSCLC from miRNA-seq data

Clinicopathological feature		n	Relevant expression of miR-182-5p (log₂x)
Clinicopathological feature		n	Mean ± SD	t/F-value	P-value
Tissue	Lung cancer	784	14.332 ± 1.042	21.214	< 0.001*
Tissue	Noncancerous	89	11.962 ± 0.994	21.214	< 0.001*
Histological type	Adenocarcinoma	448	14.273 ± 0.947	−1.785	0.075
Histological type	Squamous carcinoma	336	14.411 ± 1.154	−1.785	0.075
Gender	Male	460	14.367 ± 1.042	1.137	0.256
Gender	Female	324	14.282 ± 1.042	1.137	0.256
Age(years)	≤60	213	14.396 ± 1.040	1.169	0.243
Age(years)	> 60	546	14.297 ± 1.055	1.169	0.243
T	T1 + T2	654	14.358 ± 1.038	1.242	0.214
T	T3 + T4	127	14.232 ± 1.051	1.242	0.214
Nodes	No	509	14.315 ± 1.050	−1.182	0.238
Nodes	Yes	260	14.408 ± 1.006	−1.182	0.238
Metastasis	No	540	14.376 ± 1.041	0.328	0.743
Metastasis	Yes	21	14.302 ± 1.029	0.328	0.743
Pathologic stage	I-II	631	14.320 ± 1.063	−0.481	0.631
Pathologic stage	III-IV	145	14.366 ± 0.962	−0.481	0.631
Anatomic organ subdivision	L-Lower	112	14.285 ± 1.029	0.662^a	0.618
	L-Upper	198	14.240 ± 0.995
	R-Lower	160	14.390 ± 1.073
	R-Middle	29	14.416 ± 1.008
	R-Uppr	249	14.359 ± 1.026
Tumor location	Peripheral	187	14.342 ± 1.013	−0.210	0.834
Tumor location	Central	162	14.366 ± 1.130	−0.210	0.834

ISSN: 1755-8794