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Table 6 Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of candidate target genes of miR-182-5p

From: MiR-182-5p and its target HOXA9 in non-small cell lung cancer: a clinical and in-silico exploration with the combination of RT-qPCR, miRNA-seq and miRNA-chip

Category Item Count P-value
GO-BP axonogenesis 46 < 0.001
GO-BP axon development 48 < 0.001
GO-BP Ras protein signal transduction 45 < 0.001
GO-BP eye development 37 < 0.001
GO-BP mesenchyme development 30 < 0.001
GO-CC cell leading edge 37 < 0.001
GO-CC actin cytoskeleton 40 0.002
GO-CC cortical cytoskeleton 15 0.002
GO-CC lamellipodium 21 0.002
GO-CC cell cortex 28 0.002
GO-MF transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding 41 < 0.001
GO-MF transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding 38 < 0.001
GO-MF transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding 28 < 0.001
GO-MF proximal promoter sequence-specific DNA binding 37 < 0.001
GO-MF nucleoside-triphosphatase regulator activity 31 < 0.001
KEGG Axon guidance 21 < 0.001
KEGG Melanogenesis 15 < 0.001
KEGG Longevity regulating pathway - multiple species 11 < 0.001
KEGG Parathyroid hormone synthesis, secretion and action 14 < 0.001
KEGG Glutamatergic synapse 14 < 0.001
  1. Note: BP: biological process; CC: cellular component; MF: molecular function
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BMC Medical Genomics

ISSN: 1755-8794

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