MiR-182-5p and its target HOXA9 in non-small cell lung cancer: a clinical and in-silico exploration with the combination of RT-qPCR, miRNA-seq and miRNA-chip

Table 6 Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of candidate target genes of miR-182-5p

Category	Item	Count	P-value
GO-BP	axonogenesis	46	< 0.001
GO-BP	axon development	48	< 0.001
GO-BP	Ras protein signal transduction	45	< 0.001
GO-BP	eye development	37	< 0.001
GO-BP	mesenchyme development	30	< 0.001
GO-CC	cell leading edge	37	< 0.001
GO-CC	actin cytoskeleton	40	0.002
GO-CC	cortical cytoskeleton	15	0.002
GO-CC	lamellipodium	21	0.002
GO-CC	cell cortex	28	0.002
GO-MF	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding	41	< 0.001
GO-MF	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding	38	< 0.001
GO-MF	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	28	< 0.001
GO-MF	proximal promoter sequence-specific DNA binding	37	< 0.001
GO-MF	nucleoside-triphosphatase regulator activity	31	< 0.001
KEGG	Axon guidance	21	< 0.001
KEGG	Melanogenesis	15	< 0.001
KEGG	Longevity regulating pathway - multiple species	11	< 0.001
KEGG	Parathyroid hormone synthesis, secretion and action	14	< 0.001
KEGG	Glutamatergic synapse	14	< 0.001

ISSN: 1755-8794