Skip to main content
Fig. 2 | BMC Medical Genomics

Fig. 2

From: MEG3 promotes proliferation and inhibits apoptosis in osteoarthritis chondrocytes by miR-361-5p/FOXO1 axis

Fig. 2

MEG3 is a ceRNA of miR-361-5p in OA chondrocytes a, the binding sites of MEG3 and miR-361-5p predicted by bioinformatics analysis. b, luciferase reporter gene assay showed that the microRNA-361-5p mimic reduced the luciferase activity of MEG3-Wt in chondrocytes. c, the concentration of MEG3 and miR-361-5p in IgG or Ago2 immunoprecipitates detected by RIP and qRT-PCR. d and e, the expression of miR-361-5p in OA tissues or cells was examined by qRT-PCR. f, Spearman analysis determined that miR-361-5p was negatively associated with MEG3; *, P < 0.05 compared with Blank group or pcDNA3.1-NC group. &, P < 0.05 compared with si-NC group. Data expressed as mean ± standard deviation (SD)

Back to article page

BMC Medical Genomics

ISSN: 1755-8794

Contact us