Skip to main content
Fig. 4 | BMC Medical Genomics

Fig. 4

From: MEG3 promotes proliferation and inhibits apoptosis in osteoarthritis chondrocytes by miR-361-5p/FOXO1 axis

Fig. 4

FOXO1 is a directly target of miR-361-5p and positively regulated by MEG3. a, the putative binding site between miR-361-5p and FOXO1. b and c, dual-luciferase reporter gene assay and RIP analysis were performed to verify the correlation of miR-361-5p and FOXO1. d, FOXO1 expression was significantly decreased in OA. e and f, Spearman analyses for the relationships of FOXO1 and miR-361-5p/MEG3. g, qRT-PCR revealed that FOXO1 expression was promoted by pcDNA3.1-MEG3 while attenuated by si-MEG3. *, P < 0.05 compared with Blank group or pcDNA3.1-NC group. #, P < 0.05 compared with miR-361-5p mimics. &, P < 0.05 compared with si-NC group

Back to article page

BMC Medical Genomics

ISSN: 1755-8794

Contact us