From: Hierarchical structural component model for pathway analysis of common variants
Pathway | HisCoM-PCAa | HisCoM-PCAb | MAGMA | GSA-SNP2 |
---|---|---|---|---|
P value (q-value) | ||||
folate biosynthesis | 0.004 (0.1518) | 0.002 (0.0633) | 0.0537 (0.891) | 0.0019 (0.2936) |
hedgehog signaling pathway | 0.006 (0.1627) | 0.016 (0.2531) | 0.3073 (0.917) | 0.028 (0.5284) |
olfactory transduction* | 0.006 (0.1627) | 0.002 (0.0633) | 0.0482 (0.891) | 0.0036 (0.2936) |
biosynthesis of unsaturated fatty acids | 0.01 (0.2373) | 0.012 (0.2071) | 0.089 (0.891) | 0.0373 (0.5284) |
Alzheimer’s disease | 0.014 (0.2657) | 0.036 (0.4555) | 0.1808 (0.891) | 0.0446 (0.5284) |
calcium signaling pathway | 0.014 (0.2657) | 0.026 (0.3796) | 0.0791 0.891) | 0.0329 (0.5284) |
asthma | 0.016 (0.2761) | 0.008 (0.1687) | 0.0517 0.891) | 0.0737 (0.6529) |
acute myeloid leukemia | 0.032 (0.4302) | 0.042 (0.4621) | 0.0781 (0.891) | 0.5442 (1) |
melanogenesis | 0.034 (0.4302) | 0.012 (0.2071) | 0.0786 (0.891) | 0.0223 (0.5284) |
long term potentiation | 0.04 (0.4466) | 0.028 (0.3796) | 0.1284 (0.891) | 0.1616 (0.8349) |
phosphatidylinositol signaling system | 0.1119 (0.5185) | 0.006 (0.1424) | 0.7656 (0.9778) | 0.1107 (0.7355) |
dilated cardiomyopathy | 0.03 (0.4302) | 0.0819 (0.5188) | 0.3994 (0.917) | 0.0408 (0.5284) |
renin angiotensin system | 0.038 (0.4466) | 0.0539 (0.4621) | 0.3794 (0.917) | 0.0917 (0.6923) |