Fig. 3
From: Effects of ordered mutations on dynamics in signaling networks
Relations of structural properties with the ordered-mutation-inducing dynamics in signaling networks. (a-c) Mutation-sensitivity results with respect to the path length in HCS, KEGG, and TGL, respectively. All pairs of nodes involving an FBL were classified into ‘Shorter-path direction’ and ‘Longer-path direction’ groups where l(vi, vj) is smaller and larger than l(vj, vi), respectively. (d-f) Mutation-sensitivity results with respect to the number of paths in HCS, KEGG, and TGL, respectively. All pairs of nodes were classified into ‘More-paths direction’ and ‘Fewer-paths direction’ groups such that n(vi, vj) is smaller and larger than n(vj, vi), respectively. (g-i) Mutation-sensitivity results with respect to of the FBLs in HCS, KEGG, and TGL, respectively. All pairs of nodes were classified into ‘FBL’ and ‘Non-FBL’ groups such that any gene in the pair is involved in an FBL or not. (j-l) Order-specificity results with respect to the feedback loops in HCS, KEGG, and TGL, respectively. Time gap (T) was set to 2–20 in HCS and KEGG networks, and 1–10 in TGL networks. The error bar represents the standard error deviation