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Table 2 Multivariate Cox proportional hazard model analyses of associations between alternative exons, methylation of corresponding CpG and cancer patients’ survival

From: Genome-wide analysis reveals the association between alternative splicing and DNA methylation across human solid tumors

Tumor typeGene expressionPSIMethylation level
GenePHR(95%CI)Alternative ExonPHR(95%CI)CpGsPHR(95%CI)
BRACFAXDC20.5580.96 (0.84,1.10)30.0363.98 (1.09,0.04)cg182603970.4280.57 (0.14,2.31)
COADOBSCN0.7530.97 (0.78,1.20)1180.0010.20 (0.20,0.08)cg253183010.3800.48 (0.09,2.49)
       cg036692820.5810.72 (0.23,2.31)
HNSCABL20.4891.10 (0.84,1.42)20.0204.59 (1.27,16.58)cg034713460.0950.40 (0.14,1.17)
HNSCDNASE1L10.0031.45 (1.13,1.86)3.10.0074.40 (1.49,12.95)cg214595450.7880.84 (0.25,2.90)
HNSCRARA0.3931.16 (0.82,1.63)50.0090.08 (0.01,0.54)cg058242180.3501.93 (0.49,7.64)
KIRCATG16L20.1041.14 (0.97,0.10)4.1:4.20.0116.79 (1.55,29.83)cg218062420.18713.92 (0.28,698.07)
KIRCEGFLAM0.9571.00 (0.85,1.17)20.10.0470.43 (0.18,0.99)cg212013930.1974.73 (0.45,50.22)
KIRCEVL0.0041.47 (1.13,1.90)30.0270.32 (0.12,0.88)cg186212990.8850.84 (0.07,9.47)
KIRCFMNL10.3181.13 (0.89,1.42)13.10.0103.59 (1.37,9.44)cg197352500.2612.95 (0.45,19.42)
KIRCNAV20.2761.17 (0.88,1.54)170.01496.94 (2.48,3787.07)cg192227840.8570.82 (0.10,6.76)
       cg209497000.9971.00 (0.13,7.54)
KIRCSIGIRR0.6681.06 (0.80,1.40)20.0416.29 (1.08,36.63)cg025859060.1730.24 (0.03,1.88)
       cg230290210.0050.08 (0.01,0.47)
KIRCTBC1D140.9080.98 (0.65,1.46)40.02426.17 (1.52,449.63)cg168514820.7781.44 (0.12,17.83)
KIRCZNF5770.9751.00 (0.82,1.22)1.2:1.30.0096.05 (1.57,23.33)cg035624140.4711.59 (0.45,5.62)
       cg106351220.3202.03 (0.50,8.22)
       cg112695990.0077.39 (1.74,31.47)
       cg107834690.2142.73 (0.56,13.32)
       cg167312400.0304.41 (1.16,16.78)
       cg230100480.0534.04 (0.98,16.61)
       cg247942280.2282.28 (0.60,8.69)
KIRPC19orf250.0120.50 (0.29,0.86)2.40.0060.01 (0.00,0.26)cg166139380.6650.55 (0.04,8.14)
       cg232912000.9800.94 (0.01,163.12)
KIRPCABP10.00040.72 (0.60,0.87)3.10.00459.40 (3.63,972.14)cg242920160.0110.02 (0.00,0.42)
       cg259699920.0110.04 (0.00,0.49)
KIRPCALD10.6320.88 (0.52,1.49)20.0138.85 (1.58,49.62)cg048740310.007149.57 (3.97,5636.65)
       cg162536340.019148.62 (2.24,9849.90)
       cg249568660.02797.96 (1.70,5637.50)
KIRPCALD10.6320.88 (0.52,1.49)50.0130.11 (0.02,0.63)cg048740310.007149.57 (3.97,5636.65)
       cg162536340.019148.62 (2.24,9849.90)
       cg249568660.02797.96 (1.70,5637.50)
KIRPCCL280.9181.01 (0.82,1.25)20.0097.17 (1.64,31.37)cg041871850.3650.50 (0.11,2.26)
       cg163246330.02710.72 (1.31,87.54)
KIRPCIRBP0.0040.38 (0.20,0.73)8.2:8.30.01182.29 (2.75,2460.57)cg026448670.4803.51 (0.11,113.99)
KIRPDNASE1L10.1182.15 (0.82,5.63)3.10.03029.90 (1.40,637.29)cg214595450.2510.32 (0.05,2.24)
       cg225622190.0810.08 (0.01,1.36)
       cg248344610.2240.20 (0.02,2.63)
KIRPPIGQ0.7030.88 (0.46,1.68)30.0470.05 (0.00,0.96)cg038155520.5750.23 (0.00,38.74)
KIRPSLC9A3R20.6501.11 (0.70,1.78)30.0200.05 (0.00,0.62)cg086016730.2630.16 (0.01,3.97)
KIRPTM4SF180.0010.58 (0.41,0.81)2.10.0150.04 (0.00,0.55)cg110119130.0874.98 (0.79,31.30)
LIHCC1QTNF10.5801.03 (0.93,1.13)50.0080.27 (0.10,0.70)cg238827960.5531.24 (0.61,2.51)
LUADGALK20.0131.58 (1.10,2.26)3.10.00213.29 (2.53,69.98)cg080366680.2190.42 (0.11,1.67)
LUSCAHCYL20.1581.14 (0.95,1.36)30.0311.88 (1.06,3.33)cg156641520.9331.03 (0.51,2.06)
LUSCAQP10.0221.13 (1.02,1.26)7.10.0463.51 (1.02,12.06)cg071356290.9521.04 (0.32,3.41)
       cg045519250.7900.86 (0.28,2.65)
       cg101329170.6451.29 (0.44,3.82)
       cg118279250.1411.95 (0.80,4.73)
       cg043726740.0492.22 (1.00,4.89)
       cg250757940.0472.20 (1.01,4.79)
       cg252303630.0382.42 (1.05,5.57)
LUSCAQP10.0221.13 (1.02,1.26)7.10.0463.51 (1.02,12.06)cg269234100.0522.42 (0.99,5.90)
       cg153737670.1222.07 (0.82,5.21)
       cg180806040.0492.74 (1.00,7.50)
       cg096766690.0782.31 (0.91,5.84)
LUSCARHGAP240.2790.92 (0.80,1.07)60.042145.84 (1.20,17,748.46)cg143764670.9081.04 (0.52,2.09)
       cg138899340.9971.00 (0.48,2.11)
       cg214469550.8921.05 (0.49,2.24)
LUSCERG0.7381.03 (0.86,1.24)50.0382.25 (1.05,4.86)cg016138170.5810.78 (0.32,1.91)
LUSCFAXDC20.2851.07 (0.94,1.22)5.10.0472.09 (1.01,4.31)cg023795330.6240.76 (0.25,2.28)
LUSCGCNT20.9701.00 (0.89,1.12)6.10.0122.21 (1.19,4.11)cg134117890.1460.66 (0.37,1.16)
LUSCIL1RN0.7210.98 (0.89,1.08)30.0460.55 (0.31,0.99)cg117834970.8331.11 (0.42,2.89)
LUSCNAV10.5690.96 (0.85,1.09)60.0240.49 (0.26,0.91)cg014117860.7651.16 (0.44,3.03)
       cg050915700.9820.99 (0.39,2.50)
       cg138779740.3560.55 (0.15,1.97)
       cg160231220.3340.48 (0.11,2.13)
       cg018287330.3500.59 (0.19,1.79)
LUSCPLEC0.1331.13 (0.96,1.32)40.00623.29 (2.50,216.60)cg003294470.1170.53 (0.24,1.17)
       cg064527690.0330.41 (0.18,0.93)
PRADEXOC70.3460.61 (0.22,1.70)8.20.03840.29 (1.22,1329.36)cg044708780.6604.86 (0.00,5523.54)
PRADFHAD10.3581.14 (0.86,1.53)15.20.0410.26 (0.07,0.95)cg073120510.6755.04 (0.00,9748.17)
PRADPCDHA90.5920.94 (0.75,1.17)1.20.00714.70 (2.12,102.01)cg180293210.54828.37 (0.00,1,537,765.42)
THCAEGFLAM0.8281.06 (0.65,1.73)20.10.0280.10 (0.01,0.78)cg212013930.7051.97 (0.60,64.65)
  1. Abbreviation: KIRC Kidney renal clear cell carcinoma, KIRP Kidney renal papillary carcinoma, LUSC Lung squamous cell carcinoma, HR Hazard ratio
  2. The Cox regression model adjusted for age, gender, TNM stage, and adjuvant therapy