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Table 2 Top 15 pathways significantly influenced by upregulated and downregulared miRNAs in RPL

From: Identification of genes and miRNA associated with idiopathic recurrent pregnancy loss: an exploratory data mining study

KEGG pathway p-value Genes miRNAs
Upregulated miRNAs
 TGF-beta signaling pathway 3.89 × 10−11 52 7
 Adherens junction 1.93 × 10−10 51 7
 Cell cycle 5.00 × 10−8 78 7
 p53 signaling pathway 4.11 × 10−5 44 7
 FoxO signaling pathway 5.05 × 10−5 73 7
 Protein processing in endoplasmic reticulum 5.05 × 10−5 88 7
 Fatty acid biosynthesis 1.38 × 10−4 4 4
 Oocyte meiosis 1.85 × 10−4 58 7
 Fatty acid metabolism 3.93 × 10−4 21 5
 TNF signaling pathway 7.64 × 10−4 60 7
 Estrogen signaling pathway 6.65 × 10−3 49 7
 NOD-like receptor signaling pathway 0.018 30 7
 HIF-1 signaling pathway 0.030 51 7
 MAPK signaling pathway 0.040 111 7
 Circadian rhythm 0.042 18 7
Downregulared miRNAs
 Thyroid hormone signaling pathway 9.24 × 10−7 50 3
 ECM-receptor interaction 3.72 × 10−6 24 3
 Fatty acid elongation 8.50 × 10−5 9 3
 Signaling pathways regulating pluripotency of stem cells 1.24 × 10−4 50 3
 Prolactin signaling pathway 1.96 × 10− 4 32 3
 mRNA surveillance pathway 3.98 × 10−4 37 3
 Lysine degradation 7.17 × 10−4 18 3
 Insulin signaling pathway 1.80 × 10−3 52 3
 Progesterone-mediated oocyte maturation 2.40 × 10− 3 36 3
 Apoptosis 2.80 × 10−3 32 3
 Ubiquitin mediated proteolysis 3.45 × 10−3 52 3
 PI3K-Akt signaling pathway 4.35 × 10−3 102 3
 RNA degradation 6.25 × 10−3 31 3
 RNA transport 0.012 54 3
 Endocytosis 0.033 67 3