From: Leukocyte telomere length in patients with transfusion-dependent thalassemia
Clinical characteristics | N = 65 (%) |
---|---|
Female | 37 (54.4) |
Median age (year) (range) | 27.0 (18–57) |
Baseline pre-transfusion Hb level (g/dL) (range) | 7.1 (4.8–10.1) |
Red blood cell transfusion (unit per month) (range) | 1.67 (0.33–2) |
Type of thalassemia | |
Beta-thalassemia/Hb E disease | 39 (57.4) |
Homozygous beta-thalassemia | 24 (35.3) |
Hb H with Constant Spring disease | 2 (2.9) |
Splenectomy | 46 (67.6) |
Median serum ferritin level (mcg/dL) (range) | 1499 (272–7371) |
Median reticulocyte count (%) (range) | 5.2 (0.27–31.2) |
Median absolute reticulocyte count (×106/mm3) (range) | 155.4 (11–1370) |
Median Cardiac T2* (ms) | 38.3 |
> 20 | 54 (79.4) |
10–20 | 2 (2.9) |
< 10 | 5 (7.4) |
Median LIC (mg/g of dry weight) | 14.8 (1.3–27.0) |
< 7 | 7 (11.7) |
7–15 | 23 (38.3) |
> 15 | 30 (50.0) |
Liver enzymes (U/L) | |
Median AST (range) | 39.48 (16–136) |
Median ALT (range) | 34.98 (4–175) |
Mean NTBI (micromol/L) (range) | 6.94 (2.22–10.00) |