Table 3 Possible base editing systems to correct pathogenic variant NM_001005463.2:c.196A > G responsible for ataxia with delayed development
From: Genome scale analysis of pathogenic variants targetable for single base editing
Base editor | Editing window | Protospacer genome sequence |
|---|---|---|
A-BE3 | attgga | gaaatTggatttccggaggttgg |
Y-BE3 | attgg | gaaatTggatttccggaggttgg |
FE-BE3 | ttg | gaaatTggatttccggaggttgg |
YEE-BE3 | tt | gaaatTggatttccggaggttgg |
VQR_Cas9 | ttggattt | aaatTggatttccggaggttggaa |
YE1-VQR-Cas9 | tg | aaatTggatttccggaggttggaa |
APOBEC | aagaaatt | ggaagaaatTggatttccggagg |
APOBEC | aatTggat | gaaatTggatttccggaggttgg |
BE_PLUS | ggaagaaatTgga | agtggaagaaatTggatttccgg |
BE_PLUS | agaaatTggattt | ggaagaaatTggatttccggagg |
xCas9_BE3 | attgg | gaaatTggatttccggaggttgg |
xCas9_BE3 | ttgga | aaatTggatttccggaggttgga |
xCas9_BE3 | tggat | aatTggatttccggaggttggaa |
APOBEC3A-Cas9 | ttgga | gaaatTggatttccggaggttgg |
eA3A_xCas9 | attgg | gaaatTggatttccggaggttgg |
SaKKH_BE3 | gaagaaatt | gtggaagaaatTggatttccggaggt |
PmCDA1 | ttgga | tTggatttccggaggttggaagg |