Table 1 List of genes included in the Archer™ FusionPlex™ Heme Panel version 1 and examples of rearrangements that can be detected
From: Detection of leukemia gene fusions by targeted RNA-sequencing in routine diagnostics
Gene | Examples of rearrangements | Included in the study? | Number of cases Primary cohort / validation cohort |
|---|---|---|---|
ABL1 and BCR | t(9;22) (BCR-ABL1), other ABL1-rearrangements | Yes | 2 / 1 |
ALK | ALK-rearrangements | No | – |
CBFB | t/inv(16), del(16) (CBFB-MYH11), other CBFB-rearrangements | Yes | 1 / 1 |
FGFR1 | 8p11, FGFR1-rearrangements | No | – |
JAK2 (5′ and 3′) | t(9;12) (ETV6-JAK2), other JAK2-rearrangements | No | – |
KMT2A (MLL) (5′ and 3′) | All KMT2A-rearrangments | Yes | 10 / 2 |
MECOM (EVI1) | MECOM-rearrangements (but not inv(3)) | No | – |
MKL1 and RBM15 | t(1;22) (RBM15-MKL1) | Yes | 1 / 0 |
NOTCH | NOTCH-rearrangements (but not t(7;9)) | No | – |
NUP214 | t(6;9) (DEK-NUP214) | Yes | 1 / 0 |
PDGFRA | del(4q) (FIP1L1-PDGFRA), other PDGFRA-rearrangements | Yes | 1 / 0 |
PDGFRB | t(1;5) (PDE4DIP-PDGFRB), t(5;12) (ETV6-PDGFRB), other PDGFRB-rearrangments | Yes | 1 / 0 |
PICALM | t(10;11) (PICALM-MLLT10) | No | – |
RARA | t(15;17) (PML-RARA), t(11;17) (PLZF-RARA), other RARA-rearrangments | Yes | 3 / 1 |
RUNX1 | t(12;21) (ETV6-RUNX1), t(8;21) (RUNX1-RUNX1T1), t(16;21) (RUNX1-CBFA2T3), other RUNX1-rearrangments | Yes | 3 / 2 |
RUNX1T1 | t(8;21) (RUNX1-RUNX1T1) | Yes | 1 / 0 |
TAL1 | del(1p32) (STIL-TAL1) | Yes | 1 / 0 |
TCF3 | t(1;19) (TCF3-PBX1), t(17;19) (TCF3-HLF) | Yes | 1 / 1 |