From: Detection of leukemia gene fusions by targeted RNA-sequencing in routine diagnostics
Aberration according to AML or ALL FISH probe panel | Fusion interpretation of result from targeted RNA sequencing using Anchored multiplex PCR | Concordant with FISH result? | |
---|---|---|---|
Transcript | Number of unique reads (% of gene target) | ||
inv(16); CBFB-MYH11 | CBFB-MYH11 e5-e33 | 2068 (48%) | Yes |
t(1;19); TCF3-PBX1 | TCF3-PBX1 e16-e3 | 2216 (50%) | Yes |
t(10;11); KMT2A-MLLT10 | KMT2A-MLLT10 e9-e8 | 471 (10%) | Yes |
t(15;17); PML-RARA | PML-RARA e6-e3 | 1405 (32%) | Yes |
t(12;21); ETV6-RUNX1 | ETV6-RUNX1 e5-e3 | 2242 (11%) | Yes |
t(12;21); ETV6-RUNX1 | ETV6-RUNX1 e5-e3 | 1656 (18%) | Yes |
t(9;22); BCR-ABL1 | BCR-ABL1 e1-e2 | 2084 (49%) | Yes |
t(9;11); KMT2A-MLLT3 | KMT2A-MLLT3 e8-e6 | 803 (18%) | Yes |
No fusion,signal pattern consistent with iAMP21a | No fusion | – | Yes |
No fusion | TCF3-ZNF384 e12-e3 | 564 (54%) | Yesb |
No fusion | No fusion | – | Yes |
No fusion | No fusion | Yes |