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Fig. 1 | BMC Medical Genomics

Fig. 1

From: Integrative analyses of gene expression profile reveal potential crucial roles of mitotic cell cycle and microtubule cytoskeleton in pulmonary artery hypertension

Fig. 1

Differential expression analyses for all genes between PAH and control. a. Principal component analysis (PCA) illustrated the individual differences in the Chip expression profiles among the PAH and control groups in 49 samples. The green and red circles represent the case and control groups, respectively. The first component represent 42.84% of variance and the second component represent 9.57% of variance. The PCA plot was plotted using prcomp function in R program. b. Volcano plot showed all the gene expression change in PAH compared to the control samples. Grey represents no change in expression, blue represents downregulation (Down), and red represents upregulation (Up). Log FC reprsents log2 fold changes and p-value < 0.05 was considered as the threshold value of significant difference. The cutoff of log FC was 1.0. c. Heatmap showed the top 100 differentially expressed genes listed by listed by corrected P-values in PAH compared to the control samples. Each column represents one sample, and each row represents one gene. The gene expression values of all samples are showed as base − 2 logarithmic value. The gradual color ranging from blue to red represents the changing process from downregulated to upregulated expression

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