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Fig. 3 | BMC Medical Genomics

Fig. 3

From: Integrative analyses of gene expression profile reveal potential crucial roles of mitotic cell cycle and microtubule cytoskeleton in pulmonary artery hypertension

Fig. 3

Identification of hub genes from DEGs. a. The protein–protein interaction (PPI) network of top 100 DEGs. Red nodes represent up-regulated DEGs and green nodes represent down-regulated DEGs. The size of circles represents levers of degree (number of interaction) and the thickness of edge represent strength of interaction with combined score. b. PPI network of the genes enriched in Mitotic Cell Cycle and Microtubule Cytoskeleton Organization. The nodes represented genes, blue indicated the DEGs shared by the two biological processes and the other colors corresponded to the genes in these two biological processes. And the size of nodes indicated the number of connections. Edges denoted the interactions between two genes, and the width of an edge denoted the score of a physical interaction. c. The core module (module 1 with the MCODE score of 29.067) from the PPI network. The color shadow of each node represents the Mcode_score (degree of connection of nodes). d. Venn diagram indicated 9 hub genes overlapping from three analytic procedure (PPI, Modular and Cytohub)

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