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Table 1 The effect characteristic of miRNAs in oral squamous cell carcinoma (OSCC)

From: Construction and analysis of a lncRNA-miRNA-mRNA network based on competitive endogenous RNA reveal functional lncRNAs in oral cancer

miRNA Targets Effect characteristic Reference
hsa-miR-139-5p AKT Inhibits oral cancer cell proliferation and induces cell apoptosis [36]
hsa-miR-17-5p Casp-2/−7/− 8, Bcl-2 and DIALO Inhibits hypoxia-induced apoptosis [37]
hsa-miR-107 p53 p53 upregulates miR-107 in normal condition [38]
hsa-miR-375 Sp1 and cyclin D1 Inhibits cell growth and its expression is correlatedwith prognosis of TSCC [39]
hsa-miR-455-5p UBE2B Binds SMAD3-specific promoter regions, leads toUBE2B downregulation, and contributes to oralcancer tumorigenesis [40]
hsa-miR-137 CDK6 Arrests cell cycle at the G1-S checkpoint [41]
hsa-miR-140-5p ADAM10 Inhibits the invasion and migration of TSCC cells [42]
hsa-miR-125b-5p BAK1 Boosts the level of BAK1 that is controlling the apoptotic pathway [38]