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Table 1 The effect characteristic of miRNAs in oral squamous cell carcinoma (OSCC)

From: Construction and analysis of a lncRNA-miRNA-mRNA network based on competitive endogenous RNA reveal functional lncRNAs in oral cancer

miRNATargetsEffect characteristicReference
hsa-miR-139-5pAKTInhibits oral cancer cell proliferation and induces cell apoptosis[36]
hsa-miR-17-5pCasp-2/−7/− 8, Bcl-2 and DIALOInhibits hypoxia-induced apoptosis[37]
hsa-miR-107p53p53 upregulates miR-107 in normal condition[38]
hsa-miR-375Sp1 and cyclin D1Inhibits cell growth and its expression is correlatedwith prognosis of TSCC[39]
hsa-miR-455-5pUBE2BBinds SMAD3-specific promoter regions, leads toUBE2B downregulation, and contributes to oralcancer tumorigenesis[40]
hsa-miR-137CDK6Arrests cell cycle at the G1-S checkpoint[41]
hsa-miR-140-5pADAM10Inhibits the invasion and migration of TSCC cells[42]
hsa-miR-125b-5pBAK1Boosts the level of BAK1 that is controlling the apoptotic pathway[38]