Construction and analysis of a lncRNA-miRNA-mRNA network based on competitive endogenous RNA reveal functional lncRNAs in oral cancer

Table 1 The effect characteristic of miRNAs in oral squamous cell carcinoma (OSCC)

miRNA	Targets	Effect characteristic	Reference
hsa-miR-139-5p	AKT	Inhibits oral cancer cell proliferation and induces cell apoptosis	[36]
hsa-miR-17-5p	Casp-2/−7/− 8, Bcl-2 and DIALO	Inhibits hypoxia-induced apoptosis	[37]
hsa-miR-107	p53	p53 upregulates miR-107 in normal condition	[38]
hsa-miR-375	Sp1 and cyclin D1	Inhibits cell growth and its expression is correlatedwith prognosis of TSCC	[39]
hsa-miR-455-5p	UBE2B	Binds SMAD3-specific promoter regions, leads toUBE2B downregulation, and contributes to oralcancer tumorigenesis	[40]
hsa-miR-137	CDK6	Arrests cell cycle at the G1-S checkpoint	[41]
hsa-miR-140-5p	ADAM10	Inhibits the invasion and migration of TSCC cells	[42]
hsa-miR-125b-5p	BAK1	Boosts the level of BAK1 that is controlling the apoptotic pathway	[38]