Fig. 2

Genetic colocalization reveals shared regulatory loci and implicates causal genes underlying genetic associations between hematopoietic traits and disease end-points. a Number of traits identified at each colocalization site (max = 24). b Heat map depicting percent overlap at colocalization sites between each trait pair. In each box, the number of sites where the row-specified trait and column-specified trait colocalized was normalized to the total number of colocalization sites for the ‘row trait’. For this reason, the heat map is asymmetric. c Hierarchical clustering based on colocalization results associates related traits, which are color coded according to the key in part b. d Degree of colocalization (% overlap) reflects genetic correlation between trait pairs. Shaded area depicts the 95% prediction interval, with gray line at mean. Exemplary trait pairs are circled. Depsx, depressive symptoms. Rbc, red blood cell count. Baso, basophil cell count. Brca, breast cancer. Scz, schizophrenia. Eo%, eosinophil percentage of white blood cells (‘eo_p’) or granulocytes (‘eo_p_gran’)