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Table 6 Average significance scores for somatic variants reported in both samples for each variant caller (UZ001). For Strelka2 and Mutect2, a higher Somatic EVS and TLOD means a higher confidence in the calls, while for VarScan2 and Shimmer a lower value implies a higher confidence

From: Comparative analysis of somatic variant calling on matched FF and FFPE WGS samples

Sample

Strelka2

Mutect2

VarScan2

Shimmer

FF

17.33

51.88

0.0024

0.0160

FFPE

14.34

26.00

0.0038

0.0166