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Table 3 Characteristics of the marker data extracted from the IAMDGC exome chip

From: Statistical driver genes as a means to uncover missing heritability for age-related macular degeneration

Data

ADV

GA

CNV

IAMDGC Chip

553,261

553,261

553,261

 8 SDGs ±50 kb

1122

1122

1122

 2 Novel SDGs ±50 kb

79

79

79

 Lead IAMDGC Variants

52

52

52

 34 AMD Loci

2758

2758

2758

 34 AMD Loci and 2 Novel SDGs ±50 kb

2835

2992

2992

 34 AMD Loci and 8 SDGs ±50 kb

3351

4411

3351

  1. Values represent counts of pruned variants based on MAF and call rate. The 8 SDGs are C2, C3, LIPC, MICA, NOTCH4, PLCG2, PPARA, and RAD51B. The 2 novel SDGs are PLCG2 and PPARA. The different numbers of variants for the expanded loci analyses were attributable to the different MAFs observed for each of the advanced AMD subtypes: ADV, GA, and CNV