Statistical driver genes as a means to uncover missing heritability for age-related macular degeneration

BMC Medical Genomics

Table 5 Chip heritability estimates calculated by GREML for advanced AMD (ADV), GA, and CNV using quantitative covariates

Analyses	ADV		GA		CNV
Analyses	Estimate (%)	S.E. (%)	Estimate (%)	S.E. (%)	Estimate (%)	S.E. (%)
Full Chip (no covariates)	44.05	1.29	46.37	2.13	62.03	1.47
With Age	57.96	1.31	45.41	2.16	59.71	1.51
With 10 PCs	44.16	1.29	46.50	2.13	62.18	1.48
With Age + 10 PCs	42.06	1.31	41.24	1.97	60.21	1.51

These estimates were based on 15,656 advanced AMD (ADV) cases (2964 GA-specific cases and 10,340 CNV-specific cases) and 17,832 controls with age information in the IAMDGC data or with an age over 50. Covariates included age information available from the IAMDGC (age at diagnosis for cases and age at exam for controls) and 10 PCs calculated for each of the datasets

ISSN: 1755-8794