Skip to main content

Table 6 Epistatic interactions from pairwise logistic regression-based epistasis testing between variants in or within 50 kb of the 2 novel SDGs (PPARA and PLCG2) and the 52 AMD-associated index variants from the 2016 IAMDGC GWAS

From: Statistical driver genes as a means to uncover missing heritability for age-related macular degeneration

AMD Locus from IAMDGC GWAS

AMD SDG Locus

Epistatic Interaction

Chr

Location (bp)

rsID

Locus Name

Chr

Location (bp)

rsID

Locus Name

OR

P

1

196,704,632

rs10922109

CFH

22

46,681,141

rs35883013

PPARA

1.55

0.00015

9

76,617,720

rs10781182

MIR6130/RORB

16

81,932,165

rs4889432

PLCG2

1.09

0.00048

5

39,327,888

rs62358361

C9

16

81,821,531

rs8043845

PLCG2

0.66

0.00073

14

68,769,199

rs61985136

RAD51B

16

81,900,628

rs4243218

PLCG2

1.08

0.00079

6

3,255,581

rs204993

C2/C3/CFB

22

46,685,754

rs182313981

PPARA

0.63

0.00093

19

45,411,941

rs429358

APOE

22

46,685,754

rs182313981

PPARA

0.53

0.00099

  1. Locations are given in base pairs (bp) based on build 37 of the human genome. None of these interactions are significant after correcting for multiple testing (p < 2.31 × 10− 6). Chr: Chromosome, P: p-values from the logistic regression test, distributed as χ2 with 1 d.f
Back to article page

BMC Medical Genomics

ISSN: 1755-8794

Contact us