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Fig. 2 | BMC Medical Genomics

Fig. 2

From: Analysis of H3K4me3 and H3K27me3 bivalent promotors in HER2+ breast cancer cell lines reveals variations depending on estrogen receptor status and significantly correlates with gene expression

Fig. 2

The average density of histone modification signal around TSS according to gene expression. The visualization of the histone modification location and gene expression correlation plots for the H3K4me3 (a) and H3K27me3 (b) marks in the 4 HER2+ breast cancer cell lines. For each plot, the gene expression was clustered into three groups (Low, Medium and High expression) using kmeans, and each cluster was plotted according to the average density of the peak with respect to distance from the transcription start site (TSS) for their corresponding genes

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