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Fig. 4 | BMC Medical Genomics

Fig. 4

From: Analysis of H3K4me3 and H3K27me3 bivalent promotors in HER2+ breast cancer cell lines reveals variations depending on estrogen receptor status and significantly correlates with gene expression

Fig. 4

Enrichment analysis of genes with both marks shows only one difference between ER+ and ER-. Dot plot of the KEGG Pathway enrichment analysis for the genes that have both an H3K4me3 and H3K27me3 histone modification within -2000 to 1000 bp from the TSS for 4 HER2+ breast cancer cell lines. The number of genes with both modifications are located in the bottom brackets, the enriched pathways are labeled on the left-hand side, and gene ratio and adjusted p-vales are determined by dot size and colour respectively

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