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Table 3 The differential expression analysis for the genes that are downstream targets of the ER pathway with the trimethylation mark status shown for the four cell lines used in this study

From: Analysis of H3K4me3 and H3K27me3 bivalent promotors in HER2+ breast cancer cell lines reveals variations depending on estrogen receptor status and significantly correlates with gene expression

Genes

TCGA Mean ER-

TCGA Mean ER+

Adjusted p-value

AU565

SKBR3

MB361

UACC812

ESR1

1957.85

28,587.25

4.97E-26

Both

Both

H3K4

H3K4

TTLL4

2292.15

1222.79

5.87E-14

H3K4

H3K4

H3K4

H3K4

CA12

6494.32

26,181.72

2.39E-11

Both

H3K4

H3K4

Both

GATA3

10,042.38

30,905.96

1.78E-09

Both

Both

Both

Both

IDE

2696.24

2470.56

5.06E-06

H3K4

H3K4

H3K4

H3K4

TIMM17B

2089.91

1922.64

7.35E-06

NA

NA

NA

NA

RAB11A

13,538.06

12,663.28

1.68E-05

H3K4

H3K4

H3K4

H3K4

TFF3

11,984.35

16,748.75

4.28E-04

H3K27

H3K27

H3K4

H3K4

CYB561

20,940.65

17,868.85

5.41E-04

H3K4

Both

H3K4

H3K4

ST3GAL6

324.15

249.91

5.54E-04

NA

NA

NA

H3K27

FBP1

2520.97

5160.04

7.95E-04

H3K4

H3K4

H3K4

H3K4

LIN7A

116.18

352.67

7.53E-03

Both

Both

H3K4

Both

SOX13

4161.82

4182.33

9.74E-03

H3K4

H3K4

H3K4

H3K4

KIAA1279

2414.85

2747.07

0.01

NA

NA

NA

NA

C10orf116

3067.85

6545.65

0.01

NA

NA

NA

NA

TGFB3

4358.59

4501.40

0.01

H3K4

H3K4

H3K4

H3K4

HIF1AN

3677.74

4135.13

0.01

H3K4

H3K4

Both

Both

ANXA9

1033.79

2243.66

0.02

H3K4

NA

H3K4

H3K4

PCBP2

25,977.29

30,070.89

0.02

H3K4

H3K4

H3K4

H3K4

  1. Both referring to having both the H3K4me3 and H3K27me3 marks